Large-scale national security events present complex challenges for EMS and emergency management—demanding real-time, coordinated intelligence to safeguard both responders and the public. This session presents a case study on the operationalization of EMS data through the creation of two custom built syndromic surveillance dashboards: one developed for the 2024 Republican National Convention (RNC) in Milwaukee Wisconsin, and the other for the 2024 Democratic National Convention (DNC) in Chicago Illinois. Additionally, EMS systems leveraged real time software solutions (RescueNet Live and Zoll Online) to assist in determining patient acuity. Biospatial was also utilized for assessing syndromic surveillance with rapid data pulls. A specialized triage system was developed to retain patients to be treated within the perimeter of the NSSE footprint while adding transport for those who absolutely needed advanced care at an Emergency Department. Co-presenters Ms. Almanza, Dr. Nicholas Cozzi, Dr. Thomas Engel, and Dan Pojar will explore the end-to-end process of designing, developing, and leveraging these dashboards/software solutions to support rapid decision-making, identify emerging health trends, and enhance situational awareness across multiple operational domains. Drawing from real-world use during both conventions, the presenters will share insights on how the tools supported unified command structures, optimized EMS response, and contributed to overall public safety outcomes. Central to this effort was the cross-state collaboration between Wisconsin and Illinois EMS teams, who worked together to overcome jurisdictional barriers and data silos. This session will demonstrate how cross-agency, interoperable data systems can drive measurable improvements in response efficiency, surveillance capabilities, and event preparedness. Attendees will leave with practical strategies to replicate or adapt this model for future mass gatherings, complex incidents, and high-stakes emergency scenarios.